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M9480041.TXT
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1994-08-09
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Document 0041
DOCN M9480041
TI HIV-negative AIDS in Kentucky: a case of idiopathic CD4+ lymphopenia and
cryptococcal meningitis.
DT 9410
AU Ramirez JA; Srinath L; Ahkee S; Huang AK; Raff MJ; Department of
Medicine, University of Louisville, School of; Medicine, KY 40292.
SO South Med J. 1994 Jul;87(7):751-2. Unique Identifier : AIDSLINE
MED/94294868
AB Here we describe a case of unexplained CD4+ T-lymphocyte depletion and
cryptococcal meningitis in a patient without evidence of human
immunodeficiency virus (HIV) infection. This newly recognized syndrome
has been named idiopathic CD4+ lymphopenia (ICL). When HIV infection is
suspected in a patient with an opportunistic infection, a CD4+
lymphocyte count should be obtained, even if the patient's HIV test is
negative. Patients with persistently low CD4 counts (< 300 cells/microL,
or < 20%) who show no evidence of HIV infection, who have no defined
immunodeficiency, and who are not receiving therapy associated with CD4
depletion have disease that meets the definition of ICL, and the case
should be reported to the Centers for Disease Control.
DE *Acquired Immunodeficiency Syndrome Adult Antigens, CD4/*ANALYSIS
Case Report Fluconazole/ADMINISTRATION & DOSAGE Human *HIV
Seronegativity Kentucky/EPIDEMIOLOGY *Lymphocyte Depletion
Lymphopenia/EPIDEMIOLOGY/*IMMUNOLOGY Male Meningitis,
Cryptococcal/DRUG THERAPY/EPIDEMIOLOGY/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).